Informed by health services and population health research methods, and resourced by $6.16 million (2012-15), the objectives in theme 3 centre around outcomes along the care continuum for lifespan complex conditions as well as drug safety and effectiveness. A growing population of adults with congenital heart disease (CHD) resulted in the creation of the MAUDE Unit which was named a leading Canadian program in 2010. We are internationally known for our contributions in outcomes research using the Quebec CHD database – the largest of its kind worldwide – where methodology and data are informing efforts at the Centers for Disease Control and Prevention. We led the formation of iCACHnet, (Canadian Adult Congenital Heart Network) to foster pan-Canadian collaborations and to promote the first-time use of Canadian Institute for Health Information data for CHD populations. We are generating new disease models, leading the research agenda to promote the understanding of brain-based disability in patients with CHD and to create tailored health technology-based interventions.